POTENSI TOKOFEROL SEBAGAI ANTIOKSIDAN PADA SEDIAAN KRIM DARI FRAKSI NON POLAR CRUDE PALM OIL (CPO) DENGAN METODE DPPH (1,1-diphenyl-2-picrylhydrazyl)
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Mar 30, 2026
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Abstract
Tokoferol merupakan senyawa antioksidan alami yang banyak ditemukan dalam fraksi non-polar Crude Palm Oil (CPO). Antioksidan memiliki peran penting dalam menangkal radikal bebas yang dapat menyebabkan kerusakan kulit dan penuaan dini. Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan dari fraksi non-polar CPO dalam sediaan krim menggunakan metode DPPH (1,1-difenil-2- pikrilhidrazil). Fraksi non-polar CPO diformulasikan ke dalam krim dengan konsentrasi 0% (F0), 1% (F1), 2% (F2), dan 3% (F3). Uji aktivitas antioksidan dilakukan dengan mengukur nilai IC₅₀ masing-masing formula dan dibandingkan dengan vitamin C sebagai kontrol positif. Hasil penelitian menunjukkan bahwa krim F3 memiliki aktivitas antioksidan yang kuat dengan nilai IC₅₀ sebesar 56,167 µg/mL. Hasil uji ANOVA dan LSD menunjukkan perbedaan yang signifikan antara F0 dengan F3 dan vitamin C (p < 0,05). Selain itu, semua formula memenuhi parameter mutu fisik sediaan krim yang meliputi homogenitas, pH, viskositas, daya sebar, dan daya lekat. Dapat disimpulkan bahwa fraksi non-polar CPO memiliki potensi sebagai sumber antioksidan alami dan dapat dikembangkan dalam sediaan krim
Kata kunci: α-Tokoferol, Crude Palm Oil (CPO), Antioksidan, DPPH, Krim
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References
Aksu, K., Ozgeris, B., Taslimi, P., Naderi, A., Gulcin, I., & Goksu, S. (2016). Aktivitas antioksidan, asetilkolinesterase, dan sifat penghambatan anhidrase karbonat dari urea baru yang berasal dari fenetilamina. Archives of Pharmacal Research, 349, 944-954.
Aksu, K., Topal, F., Gulcin, I., Tumer, F., & Goksu, S. (2015). Penghambatan asetilkolinesterase dan aktivitas antioksidan dari sulfamida simetris baru yang berasal dari fenetilamina. Pharmaceutical Chemistry Letters, 348, 446-455.
Alhaji, A. M., Almeida, E. S., Carneiro, C. R., da Silva, C. A. S., Monteiro, S., & Coimbra, J. S. dos R. (2024). Palm Oil (Elaeis guineensis): A Journey through Sustainability, Processing, and Utilization. Foods, 13(17), 2814. https://doi.org/10.3390/foods13172814
Alizadeh, L., Nayebzadeh, K., & Mohammadi, A. (2015). A comparative study on the in vitro antioxidant activity of tocopherol and extracts from rosemary and Ferulago angulata on oil oxidation during deep frying of potato slices. Journal of Food Science and Technology, 53, 611-620. https://doi.org/10.1007/s13197-015-2062-2.
Almagro, L., Sabater-Jara, A., Belchí-Navarro, S., & Pedreño, M. (2021). Recent trends in the biotechnological production of tocopherols using in vitro cultures. Phytochemistry Reviews, 20, 1193 - 1207. https://doi.org/10.1007/s11101-021-09742-8.
Almeida, E. S., Carvalho, A. C. B., Soares, I. O. D. S., Valadares, L. F., Mendonça,
A. R. V., Silva, I. J., Jr., & Monteiro, S. (2019). Elucidating how two different types of bleaching earths widely used in the vegetable oils industry remove carotenes from palm oil: Equilibrium, kinetics, and thermodynamic parameters. Food Research International, 121, 785–797.
Andulaai, A. M., Ruslan, R., Ys., H., & Puspitasari, D. J. (2017). Studi Perbandingan Analisis Vitamin E Minyak Sawit Merah Tersaponifikasi Antara Metode Spektrofotometri Uv-Vis Dan Kckt. Kovalen, 3(1), 50. https://doi.org/10.22487/j24775398.2017.v3.i1.8233
Apitalau, E. A., Edy, H. J., & Mansauda, K. R. L. (2021). Formulasi Dan Uji Efektivitas Antioksidan Sediaan Krim Ekstrak Etanol Daun Salam ( Syzygium Polyanthum ( Wight ) Walpers .) Dengan Menggunakan Metode DPPH. PHARMACON, 10(1), 720–729.
Askın, H., Yılmaz, B., Gulcin, I., Taslimi, P., Bakırcı, S., Yıldız, M., & Kandemir,
N. (2018). Aktivitas antioksidan ekstrak air dari Iris taochia dan identifikasi senyawa kimia alaminya secara farmakognosi dan fitokimia. Indian Journal of Pharmaceutical Sciences, 80, 802-812.
Baharin, B. S., Latip, R. A., Che Man, Y. B., & Abdul Rahman, R. (2001). The effect of carotene extraction system on crude palm oil quality, carotene composition, and carotene stability during storage. JAOCS, Journal of the American Oil Chemists’ Society, 78(8), 851–855. https://doi.org/10.1007/s11746-001-0354-4
Boztas, M., Taslimi, P., Yavari, M.A., Gulcin, I., Sahin, E., & Menzek, A. (2019). Sintesis dan evaluasi biologis turunan bromofenol dengan gugus siklopropil: Pembukaan cincin siklopropana dengan monoester. Bioorganic Chemistry, 89, 103017.
Bulut, N., Koçyigit, U.M., Gecibesler, I.H., Dastan, T., Karci, H., Taslimi, P., Durna Dastan, S., Gulcin, I., & Cetin, A. (2018). Sintesis beberapa senyawa piridin baru yang mengandung gugus bis-1,2,4-triazol dan investigasi sifat antioksidannya, profil penghambatan enzim karbonat anhidrase dan asetilkolinesterase. Journal of Biochemical and Molecular Toxicology, 32, e22006.
Buyukokuroglu, M.E., & Gulcin, I. (2009). Sifat antioksidan dan antiradikal in vitro dari Hippophae rhamnoides L. Pharmacognosy Magazine, 4, 189-195.
Chen, Y., Tan, J., & Wang, H. (2020). Stability of Crude Palm Oil in Oxidative Environments. Journal of Food Science, 78(4), 312-318.
Choo, Y. M., et al. (2021). Antioxidant properties of palm oil and its components: A review. Journal of Food Science, 15(4), 79-88.
Codex Alimentarius Commission Request for Comments at Step 6 on the Draft Revision to the Standard for Named Vegetable Oils (CODEX STAN 210- 1999: Addition of Palm Oil with High Oleic Acid (OXG); FAO/WHO: Rome, Italy, 2017
De Almeida, E. S., da Silva Damaceno, D., Carvalho, L., Victor, P. A., dos Passos,
R. M., de Almeida Pontes, P. V., Cunha-Filho, M., Sampaio, K. A., & Monteiro, S. (2021). Thermal and physical properties of crude palm oil with higher oleic content. Applied Sciences, 11(15), 7094.
Ekinci Akdemir, F.N., Gulcin, I., & Alwasel, S. (2016). Sebuah studi komparatif tentang efek antioksidan hesperidin dan asam ellagic terhadap cedera iskemia/reperfusi otot rangka. Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 114-118.
Elmastas, M., Celik, S.M., Genc, N., Aksit, H., Erenler, R., & Gulcin, I. (2018). Aktivitas antioksidan dari teh herbal Anatolia-Origanum minutiflorum: Isolasi dan karakterisasi metabolit sekundernya. International Journal of Food Properties, 21, 374-384.
Elvira, S. (2020). Evaluasi Sediaan Topikal. Jurnal Farmasi Indonesia, 18(2), 111- 117.
Fatehi, P., Baba, A., Suk, V., & Misran, M. (2020). Preparation and characterization of palm oil in water microemulsion for application in the food industry. British Food Journal, 122, 3077-3088.
Garibov, E., Taslimi, P., Sujayev, A., Bingol, Z., Cetinkaya, S., Gulcin, I., Beydemir, S., Farzaliyev, V., Alwasel, S.H., & Supuran, C.T. (2016). Sintesis 4,5- disubstitusi-2-tioxo-1,2,3,4-tetrahydropyrimidines dan investigasi asetilkolinesterase, butirilkolinesterase, penghambatan karbonat anhidrase I/II dan aktivitas antioksidannya. Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 1-9.
Gocer, H., & Gulcin, I. (2011). Asam kafeat fenetil ester (CAPE): Korelasi struktur dan sifat antioksidan. International Journal of Food Science and Nutrition, 62, 821-825.
Isık, M., Korkmaz, M., Bursal, E., Gulcin, I., Koksal, E., & Tohma, H. (2015). Penentuan sifat antioksidan Gypsophila bitlisensis. International Journal of Pharmacology, 11, 366-371
Kedare, S.B., & Sing, R.P. (2011). Kejadian dan pengembangan metode uji antioksidan DPPH. Jurnal Pangan Teknologi, 48(4), 412-422.
Kiralan, S., Doğu-Baykut, E., Kittipongpittaya, K., Mcclements, D., & Decker, E. (2014). Increased antioxidant efficacy of tocopherols by surfactant solubilization in oil-in-water emulsions.. Journal of agricultural and food chemistry, 62 43, 10561-6 .
Koksal, E., Bursal, E., Gulcin, I., Korkmaz, M., Caglayan, C., Goren, A.C., & Alwasel, S.H. (2017). Aktivitas antioksidan dan kandungan polifenol dari timi Turki (Thymus vulgaris) yang dimonitor dengan LC-MS/MS. International Journal of Food Properties, 20, 514-525.
Molyneux (2004). The Use of The Stable Free Radical Diphenylpicryl-Hydrazyl (DPPH) for Estimating Antioxidant Activity. Songklanakarin Journal of Science and Technology, 50(June 2003), 211–219.
Montoya, C., Lopes, R., Flori, A., Cros, D., Cuellar, T., Summo, M., Espeout, S., Rivallan, R., Risterucci, A.-M. M., Bittencourt, D., & et al. (2013). Quantitative trait loci (QTLs) analysis of palm oil fatty acid composition in an interspecific pseudo-backcross from Elaeis oleifera (H.B.K.) Cortés and oil palm (Elaeis guineensis Jacq.). Tree Genetics & Genomes, 9(6), 1207– 1225.
Mozzon, M., Foligni, R., & Mannozzi, C. (2020). Current knowledge on interspecific hybrid palm oils as food and food ingredient. Foods, 9(5), 631.
Mozzon, M., Foligni, R., & Tylewicz, U. (2019). Chemical characteristics and nutritional properties of hybrid palm oils. In Hybrid palm oils (pp. 149– 170). Intech Open: London, UK.
Nair, K. P. P. (2010). Oil palm (Elaeis guineensis Jacquin). In The agronomy and economy of important tree crops of the developing world (pp. 209–236). Elsevier.
National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 14985, Alpha-Tocopherol. Retrieved January 25, 2025 from https://pubchem.ncbi.nlm.nih.gov/compound/Alpha-Tocopherol.
Oztaskın, N., Taslimi, P., Maras, A., Goksu, S., & Gulcin, I. (2017). Bromofenol antioksidan baru dengan asetilkolinesterase, butyrylcholinesterase, dan aksi penghambatan karbonat anhidrase. Bioorganic Chemistry, 74, 104-114.
Parwata, I. M. O. A. 2016. Bahan Ajar Antioksidan. Bali: Kimia Terapan Program Pascasarjana Universitas Udayana.
Patimah, R., Idawati, I., Ahdyani, R., & Indah Lestari, Y. P. (2023). POTENSI ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL DAUN KLAPA
SAWIT (Elaeis guineensis Jack.) DENGAN METODE DPPH (1,1- diphenyl-2-picrylhydrazyl). Journal of Pharmacopolium, 6(1), 73–80. https://doi.org/10.36465/jop.v6i1.1102
Pereira, P. H. F., Souza, N. F., Ornaghi, H. L., & de Freitas, M. R. (2020). Comparative analysis of different chlorine-free extraction on oil palm mesocarp fiber. Industrial Crops and Products, 150, 112305.
Perera, S. (2014). Oil palm and coconut. In Alien gene transfer in crop plants (Vol.
2, pp. 231–252). Springer.
Prasetyo, R., Putri, S., & Hartono, B. (2023). Potensi Tokoferol dalam Produk Kosmetik Berbasis Minyak Sawit. Jurnal Farmasi dan Kosmetika, 18(2), 30-40.
Pratama, A. N., & Busman, H. (2020). Potensi Antioksidan Kedelai (Glycine Max L) Terhadap Penangkapan Radikal Bebas. Jurnal Ilmiah Kesehatan Sandi Husada, 11(1), 497–504. https://doi.org/10.35816/jiskh.v11i1.333
Pratiwi, Denia, et al. "The Combination of Turmeric (Curcuma Domestica) Rhizome Extract and Collagen in A Serum Formulation as an Antioxidant." Borneo Journal of Pharmacy, vol. 4, no. 1, 2021, pp. 36-42, doi:10.33084/bjop.v4i1.1578.
Prevc, T., Levart, A., Cigić, I., Salobir, J., Ulrih, N., & Cigić, B. (2015). Rapid Estimation of Tocopherol Content in Linseed and Sunflower Oils-Reactivity and Assay. Molecules, 20, 14777 - 14790.
https://doi.org/10.3390/molecules200814777.
Priyanto, A., et al. (2019). Evaluasi Titik Leleh Krim. Jurnal Riset Farmasi dan Kosmetik, 10(2), 134-138.
Purnama, K. O., Setyaningsih, D., Hambali, E., & Taniwiryono, D. (2020). Processing, characteristics, and potential application of red palm oil—A review. International Journal of Oil Palm, 3, 40–55.
Putri, M., et al. (2022). Standar pH untuk Sediaan Topikal. Jurnal Farmasi Klinik, 9(3), 123-128.
Rahman, R., et al. (2023). Sistem Perakaran Kelapa Sawit dan Adaptasi Terhadap Kondisi Lingkungan. Agricultural Research Journal, 7(2), 69-78.
Rahmawati, E., & Wijaya, D. (2021). Pengelolaan Perkebunan Kelapa Sawit Ramah Lingkungan di Indonesia. Jurnal Lingkungan Hidup, 25(3), 78-85.
Rahmiwati, et al. (2018). Metode Saponifikasi pada Ekstraksi Vitamin E dari Minyak Kelapa Sawit Mentah. Jurnal Sains & Teknologi, 20(4), 123-130.
Rao, R. S. P., & Møller, I. M. (2011). Pattern of occurrence and occupancy of carbonylation sites in proteins. Proteomics, 11(21), 4166–4173.
Redondo-Cuevas, L., Castellano, G., Torrens, F., & Raikos, V. (2018). Revealing the relationship between vegetable oil composition and oxidative stability: A multifactorial approach. Journal of Food Composition and Analysis, 66, 221–229.
Rohaya, M. A., et al. (2019). Carotenoids in crude palm oil and their potential health benefits. Asia Pacific Journal of Clinical Nutrition, 28(3), 345-353.
Santoso, H., & Wijaya, M. (2022). Analisis Kandungan Tokoferol pada Varietas Kelapa Sawit AVROS dan EO. Jurnal Teknologi Perkebunan, 11(3), 89-95.
Shahidi, F., & Zhong, Y. (2011). Meninjau kembali teori paradoks kutub: Sebuah tinjauan kritis. Journal of Agricultural and Food Chemistry, 59, 3499-3504.
Shahidi, F., & Zhong, Y. (2015). Pengukuran aktivitas antioksidan. Journal of Functional Foods, 18, 757-781.
Shantabi, L., Jagetia, G.C., Ali, M.A., Singh, T.T., & Devi, S.V. (2014). Potensi antioksidan ekstrak daun Croton caudatus secara in vitro. Translational Medicine and Biotechnology, 2, 1-15.
Sharon, N., Anam, S., & Yuliet. (2013). Formulasi Krim Antioksidan Ekstrak Etanol Bawang Hutan (Eleutherine palmifolia L. Merr). Online Jurnal of Natural Science, 2(3), 111–122.
Siahaan, R., Mulia, T., & Zulkarnain, A. (2022). The Chemical Composition and Antioxidant Potential of Crude Palm Oil. Journal of Agricultural Science, 30(1), 45-53.
Wahyuni, D. (2019). Pengaruh Viskositas terhadap Stabilitas Krim. Jurnal Teknologi Farmasi, 11(4), 34-39.
Widyaningsih, A., et al. (2023). Pengelolaan Lingkungan dalam Industri Kelapa Sawit: Studi Kasus di Kalimantan. Jurnal Teknologi Hijau, 15(2), 100-110.
Wijaya, S., Ramadhani, M., & Kusuma, P. (2023). Applications of Palm Oil in the Food and Non-Food Industry. Palm Oil Journal, 47(7), 96-101.
Aksu, K., Topal, F., Gulcin, I., Tumer, F., & Goksu, S. (2015). Penghambatan asetilkolinesterase dan aktivitas antioksidan dari sulfamida simetris baru yang berasal dari fenetilamina. Pharmaceutical Chemistry Letters, 348, 446-455.
Alhaji, A. M., Almeida, E. S., Carneiro, C. R., da Silva, C. A. S., Monteiro, S., & Coimbra, J. S. dos R. (2024). Palm Oil (Elaeis guineensis): A Journey through Sustainability, Processing, and Utilization. Foods, 13(17), 2814. https://doi.org/10.3390/foods13172814
Alizadeh, L., Nayebzadeh, K., & Mohammadi, A. (2015). A comparative study on the in vitro antioxidant activity of tocopherol and extracts from rosemary and Ferulago angulata on oil oxidation during deep frying of potato slices. Journal of Food Science and Technology, 53, 611-620. https://doi.org/10.1007/s13197-015-2062-2.
Almagro, L., Sabater-Jara, A., Belchí-Navarro, S., & Pedreño, M. (2021). Recent trends in the biotechnological production of tocopherols using in vitro cultures. Phytochemistry Reviews, 20, 1193 - 1207. https://doi.org/10.1007/s11101-021-09742-8.
Almeida, E. S., Carvalho, A. C. B., Soares, I. O. D. S., Valadares, L. F., Mendonça,
A. R. V., Silva, I. J., Jr., & Monteiro, S. (2019). Elucidating how two different types of bleaching earths widely used in the vegetable oils industry remove carotenes from palm oil: Equilibrium, kinetics, and thermodynamic parameters. Food Research International, 121, 785–797.
Andulaai, A. M., Ruslan, R., Ys., H., & Puspitasari, D. J. (2017). Studi Perbandingan Analisis Vitamin E Minyak Sawit Merah Tersaponifikasi Antara Metode Spektrofotometri Uv-Vis Dan Kckt. Kovalen, 3(1), 50. https://doi.org/10.22487/j24775398.2017.v3.i1.8233
Apitalau, E. A., Edy, H. J., & Mansauda, K. R. L. (2021). Formulasi Dan Uji Efektivitas Antioksidan Sediaan Krim Ekstrak Etanol Daun Salam ( Syzygium Polyanthum ( Wight ) Walpers .) Dengan Menggunakan Metode DPPH. PHARMACON, 10(1), 720–729.
Askın, H., Yılmaz, B., Gulcin, I., Taslimi, P., Bakırcı, S., Yıldız, M., & Kandemir,
N. (2018). Aktivitas antioksidan ekstrak air dari Iris taochia dan identifikasi senyawa kimia alaminya secara farmakognosi dan fitokimia. Indian Journal of Pharmaceutical Sciences, 80, 802-812.
Baharin, B. S., Latip, R. A., Che Man, Y. B., & Abdul Rahman, R. (2001). The effect of carotene extraction system on crude palm oil quality, carotene composition, and carotene stability during storage. JAOCS, Journal of the American Oil Chemists’ Society, 78(8), 851–855. https://doi.org/10.1007/s11746-001-0354-4
Boztas, M., Taslimi, P., Yavari, M.A., Gulcin, I., Sahin, E., & Menzek, A. (2019). Sintesis dan evaluasi biologis turunan bromofenol dengan gugus siklopropil: Pembukaan cincin siklopropana dengan monoester. Bioorganic Chemistry, 89, 103017.
Bulut, N., Koçyigit, U.M., Gecibesler, I.H., Dastan, T., Karci, H., Taslimi, P., Durna Dastan, S., Gulcin, I., & Cetin, A. (2018). Sintesis beberapa senyawa piridin baru yang mengandung gugus bis-1,2,4-triazol dan investigasi sifat antioksidannya, profil penghambatan enzim karbonat anhidrase dan asetilkolinesterase. Journal of Biochemical and Molecular Toxicology, 32, e22006.
Buyukokuroglu, M.E., & Gulcin, I. (2009). Sifat antioksidan dan antiradikal in vitro dari Hippophae rhamnoides L. Pharmacognosy Magazine, 4, 189-195.
Chen, Y., Tan, J., & Wang, H. (2020). Stability of Crude Palm Oil in Oxidative Environments. Journal of Food Science, 78(4), 312-318.
Choo, Y. M., et al. (2021). Antioxidant properties of palm oil and its components: A review. Journal of Food Science, 15(4), 79-88.
Codex Alimentarius Commission Request for Comments at Step 6 on the Draft Revision to the Standard for Named Vegetable Oils (CODEX STAN 210- 1999: Addition of Palm Oil with High Oleic Acid (OXG); FAO/WHO: Rome, Italy, 2017
De Almeida, E. S., da Silva Damaceno, D., Carvalho, L., Victor, P. A., dos Passos,
R. M., de Almeida Pontes, P. V., Cunha-Filho, M., Sampaio, K. A., & Monteiro, S. (2021). Thermal and physical properties of crude palm oil with higher oleic content. Applied Sciences, 11(15), 7094.
Ekinci Akdemir, F.N., Gulcin, I., & Alwasel, S. (2016). Sebuah studi komparatif tentang efek antioksidan hesperidin dan asam ellagic terhadap cedera iskemia/reperfusi otot rangka. Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 114-118.
Elmastas, M., Celik, S.M., Genc, N., Aksit, H., Erenler, R., & Gulcin, I. (2018). Aktivitas antioksidan dari teh herbal Anatolia-Origanum minutiflorum: Isolasi dan karakterisasi metabolit sekundernya. International Journal of Food Properties, 21, 374-384.
Elvira, S. (2020). Evaluasi Sediaan Topikal. Jurnal Farmasi Indonesia, 18(2), 111- 117.
Fatehi, P., Baba, A., Suk, V., & Misran, M. (2020). Preparation and characterization of palm oil in water microemulsion for application in the food industry. British Food Journal, 122, 3077-3088.
Garibov, E., Taslimi, P., Sujayev, A., Bingol, Z., Cetinkaya, S., Gulcin, I., Beydemir, S., Farzaliyev, V., Alwasel, S.H., & Supuran, C.T. (2016). Sintesis 4,5- disubstitusi-2-tioxo-1,2,3,4-tetrahydropyrimidines dan investigasi asetilkolinesterase, butirilkolinesterase, penghambatan karbonat anhidrase I/II dan aktivitas antioksidannya. Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 1-9.
Gocer, H., & Gulcin, I. (2011). Asam kafeat fenetil ester (CAPE): Korelasi struktur dan sifat antioksidan. International Journal of Food Science and Nutrition, 62, 821-825.
Isık, M., Korkmaz, M., Bursal, E., Gulcin, I., Koksal, E., & Tohma, H. (2015). Penentuan sifat antioksidan Gypsophila bitlisensis. International Journal of Pharmacology, 11, 366-371
Kedare, S.B., & Sing, R.P. (2011). Kejadian dan pengembangan metode uji antioksidan DPPH. Jurnal Pangan Teknologi, 48(4), 412-422.
Kiralan, S., Doğu-Baykut, E., Kittipongpittaya, K., Mcclements, D., & Decker, E. (2014). Increased antioxidant efficacy of tocopherols by surfactant solubilization in oil-in-water emulsions.. Journal of agricultural and food chemistry, 62 43, 10561-6 .
Koksal, E., Bursal, E., Gulcin, I., Korkmaz, M., Caglayan, C., Goren, A.C., & Alwasel, S.H. (2017). Aktivitas antioksidan dan kandungan polifenol dari timi Turki (Thymus vulgaris) yang dimonitor dengan LC-MS/MS. International Journal of Food Properties, 20, 514-525.
Molyneux (2004). The Use of The Stable Free Radical Diphenylpicryl-Hydrazyl (DPPH) for Estimating Antioxidant Activity. Songklanakarin Journal of Science and Technology, 50(June 2003), 211–219.
Montoya, C., Lopes, R., Flori, A., Cros, D., Cuellar, T., Summo, M., Espeout, S., Rivallan, R., Risterucci, A.-M. M., Bittencourt, D., & et al. (2013). Quantitative trait loci (QTLs) analysis of palm oil fatty acid composition in an interspecific pseudo-backcross from Elaeis oleifera (H.B.K.) Cortés and oil palm (Elaeis guineensis Jacq.). Tree Genetics & Genomes, 9(6), 1207– 1225.
Mozzon, M., Foligni, R., & Mannozzi, C. (2020). Current knowledge on interspecific hybrid palm oils as food and food ingredient. Foods, 9(5), 631.
Mozzon, M., Foligni, R., & Tylewicz, U. (2019). Chemical characteristics and nutritional properties of hybrid palm oils. In Hybrid palm oils (pp. 149– 170). Intech Open: London, UK.
Nair, K. P. P. (2010). Oil palm (Elaeis guineensis Jacquin). In The agronomy and economy of important tree crops of the developing world (pp. 209–236). Elsevier.
National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 14985, Alpha-Tocopherol. Retrieved January 25, 2025 from https://pubchem.ncbi.nlm.nih.gov/compound/Alpha-Tocopherol.
Oztaskın, N., Taslimi, P., Maras, A., Goksu, S., & Gulcin, I. (2017). Bromofenol antioksidan baru dengan asetilkolinesterase, butyrylcholinesterase, dan aksi penghambatan karbonat anhidrase. Bioorganic Chemistry, 74, 104-114.
Parwata, I. M. O. A. 2016. Bahan Ajar Antioksidan. Bali: Kimia Terapan Program Pascasarjana Universitas Udayana.
Patimah, R., Idawati, I., Ahdyani, R., & Indah Lestari, Y. P. (2023). POTENSI ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL DAUN KLAPA
SAWIT (Elaeis guineensis Jack.) DENGAN METODE DPPH (1,1- diphenyl-2-picrylhydrazyl). Journal of Pharmacopolium, 6(1), 73–80. https://doi.org/10.36465/jop.v6i1.1102
Pereira, P. H. F., Souza, N. F., Ornaghi, H. L., & de Freitas, M. R. (2020). Comparative analysis of different chlorine-free extraction on oil palm mesocarp fiber. Industrial Crops and Products, 150, 112305.
Perera, S. (2014). Oil palm and coconut. In Alien gene transfer in crop plants (Vol.
2, pp. 231–252). Springer.
Prasetyo, R., Putri, S., & Hartono, B. (2023). Potensi Tokoferol dalam Produk Kosmetik Berbasis Minyak Sawit. Jurnal Farmasi dan Kosmetika, 18(2), 30-40.
Pratama, A. N., & Busman, H. (2020). Potensi Antioksidan Kedelai (Glycine Max L) Terhadap Penangkapan Radikal Bebas. Jurnal Ilmiah Kesehatan Sandi Husada, 11(1), 497–504. https://doi.org/10.35816/jiskh.v11i1.333
Pratiwi, Denia, et al. "The Combination of Turmeric (Curcuma Domestica) Rhizome Extract and Collagen in A Serum Formulation as an Antioxidant." Borneo Journal of Pharmacy, vol. 4, no. 1, 2021, pp. 36-42, doi:10.33084/bjop.v4i1.1578.
Prevc, T., Levart, A., Cigić, I., Salobir, J., Ulrih, N., & Cigić, B. (2015). Rapid Estimation of Tocopherol Content in Linseed and Sunflower Oils-Reactivity and Assay. Molecules, 20, 14777 - 14790.
https://doi.org/10.3390/molecules200814777.
Priyanto, A., et al. (2019). Evaluasi Titik Leleh Krim. Jurnal Riset Farmasi dan Kosmetik, 10(2), 134-138.
Purnama, K. O., Setyaningsih, D., Hambali, E., & Taniwiryono, D. (2020). Processing, characteristics, and potential application of red palm oil—A review. International Journal of Oil Palm, 3, 40–55.
Putri, M., et al. (2022). Standar pH untuk Sediaan Topikal. Jurnal Farmasi Klinik, 9(3), 123-128.
Rahman, R., et al. (2023). Sistem Perakaran Kelapa Sawit dan Adaptasi Terhadap Kondisi Lingkungan. Agricultural Research Journal, 7(2), 69-78.
Rahmawati, E., & Wijaya, D. (2021). Pengelolaan Perkebunan Kelapa Sawit Ramah Lingkungan di Indonesia. Jurnal Lingkungan Hidup, 25(3), 78-85.
Rahmiwati, et al. (2018). Metode Saponifikasi pada Ekstraksi Vitamin E dari Minyak Kelapa Sawit Mentah. Jurnal Sains & Teknologi, 20(4), 123-130.
Rao, R. S. P., & Møller, I. M. (2011). Pattern of occurrence and occupancy of carbonylation sites in proteins. Proteomics, 11(21), 4166–4173.
Redondo-Cuevas, L., Castellano, G., Torrens, F., & Raikos, V. (2018). Revealing the relationship between vegetable oil composition and oxidative stability: A multifactorial approach. Journal of Food Composition and Analysis, 66, 221–229.
Rohaya, M. A., et al. (2019). Carotenoids in crude palm oil and their potential health benefits. Asia Pacific Journal of Clinical Nutrition, 28(3), 345-353.
Santoso, H., & Wijaya, M. (2022). Analisis Kandungan Tokoferol pada Varietas Kelapa Sawit AVROS dan EO. Jurnal Teknologi Perkebunan, 11(3), 89-95.
Shahidi, F., & Zhong, Y. (2011). Meninjau kembali teori paradoks kutub: Sebuah tinjauan kritis. Journal of Agricultural and Food Chemistry, 59, 3499-3504.
Shahidi, F., & Zhong, Y. (2015). Pengukuran aktivitas antioksidan. Journal of Functional Foods, 18, 757-781.
Shantabi, L., Jagetia, G.C., Ali, M.A., Singh, T.T., & Devi, S.V. (2014). Potensi antioksidan ekstrak daun Croton caudatus secara in vitro. Translational Medicine and Biotechnology, 2, 1-15.
Sharon, N., Anam, S., & Yuliet. (2013). Formulasi Krim Antioksidan Ekstrak Etanol Bawang Hutan (Eleutherine palmifolia L. Merr). Online Jurnal of Natural Science, 2(3), 111–122.
Siahaan, R., Mulia, T., & Zulkarnain, A. (2022). The Chemical Composition and Antioxidant Potential of Crude Palm Oil. Journal of Agricultural Science, 30(1), 45-53.
Wahyuni, D. (2019). Pengaruh Viskositas terhadap Stabilitas Krim. Jurnal Teknologi Farmasi, 11(4), 34-39.
Widyaningsih, A., et al. (2023). Pengelolaan Lingkungan dalam Industri Kelapa Sawit: Studi Kasus di Kalimantan. Jurnal Teknologi Hijau, 15(2), 100-110.
Wijaya, S., Ramadhani, M., & Kusuma, P. (2023). Applications of Palm Oil in the Food and Non-Food Industry. Palm Oil Journal, 47(7), 96-101.